Amyloid Precursor Protein Expression Modulates Intestine Immune Phenotype
نویسندگان
چکیده
منابع مشابه
Binding of F-spondin to amyloid- precursor protein: A candidate amyloid- precursor protein ligand that modulates amyloid- precursor protein cleavage
Amyloidprecursor protein (APP), a type I membrane protein, is physiologically processed by or -secretases that cleave APP N-terminal to the transmembrane region. Extracellular -cleavage of APP generates a large secreted N-terminal fragment, and a smaller cellular C-terminal fragment. Subsequent -secretase cleavage in the transmembrane region of the C-terminal fragment induces secretion of small...
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of APP expression and processing in vivo, we used brain and cerebral microvessels from eNOS-deficient (eNOS / ) mice. Brain tissue from eNOS / mice had statistically higher APP and BACE1 protein levels, as well as increased BACE1 enzyme activity and A (A 1-42 wild-type control, 0.737pg/mg; eNOS / , 1.475 pg/mg; P<0.05), compared with wild-type controls (n 6 to 8 animals per background). Brain m...
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The Swedish mutation (K595N/M596L) of amyloid precursor protein (APP-swe) has been known to increase abnormal cleavage of cellular APP by Beta-secretase (BACE), which causes tau protein hyperphosphorylation and early-onset Alzheimer's disease (AD). Here, we analyzed the effect of APP-swe in global gene expression using deep transcriptome sequencing technique. We found 283 genes were down-regula...
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ژورنال
عنوان ژورنال: Journal of Neuroimmune Pharmacology
سال: 2011
ISSN: 1557-1890,1557-1904
DOI: 10.1007/s11481-011-9327-y